By Jeffrey Archer
It sort of feels blameless adequate. A disgraced British colonel bequeaths a mysterious letter to his basically son. however the second Adam Scott opens the yellowing envelope, he units into movement a perilous chain of occasions that threatens to shake the very foundations of the loose world.
Within days, Adam's lover is brutally murdered and he's operating for his existence in the course of the nice towns of Europe, pursued not just by means of the KGB, yet through the CIA and his personal countrymen besides. Their universal motive is to kill him earlier than the reality comes out. whereas strong males in smoke-filled rooms plot ever extra inventive technique of destroying him, Adam unearths himself betrayed and deserted even through these he holds so much dear.
When eventually he involves comprehend what he's in ownership of, he's much more made up our minds to guard it, for it's greater than a question of lifestyles and death-it's an issue of honor.
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Extra info for A Matter of Honor
On the other hand, the cytotoxic activity to K562 was slightly reduced (10--20%), as compared with control cultures (Fig. 4). These results show that endogenously produced IFN--y is essential to the proliferation and cytotoxicity of MLC but not to the lytic activity of natural killer cells, which is responsible for K562-cell killing. By using affinity-purified human antibodies to IFN--y we definitively demonstrated their unique ability to neutralize certain immunomodulating activities of IFN--y but not its antiviral and antiproliferative activity.
The characterization of human anti-cytokine autoantibodies revealed that they are polyclonal in nature and belong almost exclusively to the IgG class (14, 15). Those directed to IL-IO' are for almost 50% of the IgG4 subclass whereas anti-IFN-, and anti-IL6 autoantibodies were characterized as IgG I . Importantly, the serum levels of ACAs can vary significantly during infectious diseases with high levels at the height of the disease and a significant reduction after disease resolution (16). This suggests that when a specific cytokine exceeds a critical treshold level, ACAs may be compensatorily increased.
ALLOTRANSPLANT REJECTION Rejection of tumor, skin and heart allografts delayed by mABs anti-IFN--y. KAPOSI'S SARCOMA (KS) IFN--y induces normal endothelial cells to acquire the phenotype of KS cells. KS lesions blocked by mABs anti-IFN-T flow cytometric assay [17-18]. It remains yet unclear why the neutralizing effects of the immunoglobulins disappeared 13 days after infection, but this may be related either to preferential consumption of the neutralizing antibodies, to a switch in the epitope antibody repertoire or to an altered ratio of cytokine neutralizing to cytokine enhancing antibodies .
A Matter of Honor by Jeffrey Archer