New PDF release: Alzheimer's disease : life course perspectives on risk

By Amy Borenstein, James Mortimer

ISBN-10: 0124171540

ISBN-13: 9780124171541

ISBN-10: 0128045388

ISBN-13: 9780128045381

Alzheimer's sickness: Lifecourse views on danger relief summarizes the transforming into physique of information at the distribution and reasons of Alzheimer’s sickness (AD) in human populations, supplying the reader with wisdom on how we outline the disorder and what its danger and protecting elements are within the context of a life-course process.

At the belief of the e-book, the reader will comprehend why Alzheimer’s affliction most probably starts at perception, then progresses via early-life and grownup probability elements that eventually influence the stability among pathologic insults within the mind and the power of the mind to change affliction signs. unlike edited volumes which can have little team spirit, this publication makes a speciality of an built-in life-course method of the epidemiology of dementia, particularly, Alzheimer’s disorder.

  • Reviews the present technological know-how surrounding Alzheimer’s disease
  • Provides a primer of foundational wisdom at the disease's epidemiology and biostatistics
  • Utilizes a life-course method, offering a singular and built-in view of the evolution of this affliction from genes to mind reserve
  • Uses the ‘threshold model’—a concept first defined via Dr. Mortimer and generally authorised today—which contains the belief of hazard elements for the pathology and expression of the disorder
  • Proposes that enhancing mind overall healthiness via modifiable behaviors can hold up illness onset until eventually a later age
  • Examines the way forward for prevention of Alzheimer’s illness, an issue of serious present interest

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Extra info for Alzheimer's disease : life course perspectives on risk reduction

Example text

2014). , 2003). The sampling approach is preferred over the screening methodology in that persons from all cognitive strata are sampled, producing less bias, and the results are then weighted back to the original target population to estimate prevalence or incidence rates. However, if the screening methodology is used and a high cut-point is selected on the cognitive screen, one may argue that there are few true cases to be detected above the cut-point, and if they are there, they would not meet dementia criteria.

NaMCI-single domain, the least common type, is associated with frontotemporal dementia and dementia with Lewy bodies (Petersen, 2004). Therefore, the MCI sub-diagnosis may assist the physician and patient in determining what the eventual outcome will be. What was viewed in the 1980s and 1990s as a dichotomous state (demented or not demented) and later as three distinct states (normal, MCI, and AD) is now recognized as a continuous cognitive trajectory. 2 Cognitive continuum showing the overlap between normal aging, mild cognitive impairment, and Alzheimer’s disease.

Individuals aged 85 and over are more likely to have multiple brain pathologies. Therefore, defining a single cause for dementia will be more difficult than it is in younger people. These concepts are covered more thoroughly in Chapter 4. For our discussion here, the main point is that the clinical diagnosis can be misclassified, even in the hands of seasoned diagnosticians. This is due to the complexity of the disease and the need to sometimes follow a patient in time in order to feel more comfortable with the initial diagnosis.

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Alzheimer's disease : life course perspectives on risk reduction by Amy Borenstein, James Mortimer


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