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By Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)

ISBN-10: 9401063885

ISBN-13: 9789401063883

ISBN-10: 9401156646

ISBN-13: 9789401156646

This booklet, written via major authors within the box, is the 1st to house all features of cytokine antibodies, from attempt method and standardization to organic effects and services. It encompasses antibodies brought on through cytokines used therapeutically and antiviral antibodies. to appreciate the biology, the consequences of cytokine antibodies in experimental animal types and sufferers also are mentioned. The ebook is meant for researchers of cytokine biology, pharmaceutical businesses constructing cytokines and cytokine antibodies as cures, and clinicians attracted to modulating the immune approach as therapy.

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Additional resources for Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals

Example text

On the other hand, the cytotoxic activity to K562 was slightly reduced (10--20%), as compared with control cultures (Fig. 4). These results show that endogenously produced IFN--y is essential to the proliferation and cytotoxicity of MLC but not to the lytic activity of natural killer cells, which is responsible for K562-cell killing. By using affinity-purified human antibodies to IFN--y we definitively demonstrated their unique ability to neutralize certain immunomodulating activities of IFN--y but not its antiviral and antiproliferative activity.

The characterization of human anti-cytokine autoantibodies revealed that they are polyclonal in nature and belong almost exclusively to the IgG class (14, 15). Those directed to IL-IO' are for almost 50% of the IgG4 subclass whereas anti-IFN-, and anti-IL6 autoantibodies were characterized as IgG I . Importantly, the serum levels of ACAs can vary significantly during infectious diseases with high levels at the height of the disease and a significant reduction after disease resolution (16). This suggests that when a specific cytokine exceeds a critical treshold level, ACAs may be compensatorily increased.

ALLOTRANSPLANT REJECTION Rejection of tumor, skin and heart allografts delayed by mABs anti-IFN--y. KAPOSI'S SARCOMA (KS) IFN--y induces normal endothelial cells to acquire the phenotype of KS cells. KS lesions blocked by mABs anti-IFN-T flow cytometric assay [17-18]. It remains yet unclear why the neutralizing effects of the immunoglobulins disappeared 13 days after infection, but this may be related either to preferential consumption of the neutralizing antibodies, to a switch in the epitope antibody repertoire or to an altered ratio of cytokine neutralizing to cytokine enhancing antibodies [19].

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Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals by Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)


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