By Dennis E Vance
Learn at the biochemistry and molecular biology of lipids and lipoproteins has skilled notable progress within the final two decades, rather with the belief that many alternative periods of lipids play basic roles in ailments similar to middle illness, weight problems, diabetes, melanoma and neurodegenerative problems. The fifth version of this booklet has been written with significant ambitions. the 1st aim is to supply scholars and lecturers with a sophisticated up to date textbook overlaying the main parts of present curiosity within the lipid box. The chapters are written for college kids and researchers accustomed to the overall recommendations of lipid metabolism yet who desire to extend their wisdom during this quarter. the second one aim is to supply a reference textual content for scientists who're approximately to go into the sector of lipids, lipoproteins and membranes and who desire to examine extra approximately this sector of study. all the chapters were widely up-to-date because the 4th variation seemed in 2002. Key good points: * Represents a bridge among the superficial insurance of the lipid box present in uncomplicated biochemistry textual content books and the hugely really good fabric contained in medical assessment articles and monographs. * permits scientists to familiarize yourself with contemporary advancements regarding their very own learn pursuits, and may support scientific researchers and scientific scholars preserve abreast of advancements in simple technological know-how which are vital for next medical advances. * Serves as a common reference ebook for scientists learning lipids, lipoproteins and membranes and as a sophisticated and up to date textbook for lecturers and scholars who're conversant in the elemental suggestions of lipid biochemistry learn more... content material: useful roles of lipids in membranes / William Dowhan, Mikhail Bogdanov, and Eugenia Mileykovskaya -- Lipid changes of proteins / Anant ok. Menon -- Fatty acid and phospholipid metabolism in prokaryotes / Charles O. Rock -- Lipid metabolism in crops / Katherine M. Schmid and John B. Ohlrogge -- Oxidation of fatty acids in eukaryotes / Horst Schulz -- Fatty acid synthesis in eukaryotes / Hei Sook Sul and Stuart Smith -- Fatty acid desaturation and chain elongation in mammals / Makoto Miyazaki and James M. Ntambi -- Phospholipid biosynthesis in eukaryotes / Dennis E. Vance and Jean E. Vance -- Ether-linked lipids and their bioactive species / Thomas M. McIntyre, Fred Snyder, and Gopal okay. Marathe -- Lipid metabolism in adipose tissue / Ann V. Hertzel ... [et al.] -- Phospholipases / David C. Wilton -- The eicosanoids : cyclooxygenase, lipoxygenase, and epoxygenase pathways / William L. Smith and Robert C. Murphy -- Sphingolipids / Alfred H. Merrill, Jr. -- ldl cholesterol biosynthesis / Laura Liscum -- Metabolism and serve as of bile acids / Luis B. Agellon -- Lipid meeting into phone membranes / Dennis R. Voelker -- Lipoprotein constitution / Ana Jonas and Michael C. Phillips -- meeting and secretion of triacylglycerol-rich lipoproteins / Jean E. Vance and Khosrow Adeli -- Dynamics of lipoprotein shipping within the circulatory approach / Christopher J. Fielding and Phoebe E. Fielding -- Lipoprotein receptors / Wolfgang J. Schneider -- Lipids and atherosclerosis / Ira Tabas. summary: study at the biochemistry and molecular biology of lipids and lipoproteins has skilled extraordinary progress within the final two decades, rather with the conclusion that many various periods of lipids play basic roles in ailments reminiscent of center ailment, weight problems, diabetes, melanoma and neurodegenerative problems. The fifth variation of this booklet has been written with significant targets. the 1st target is to supply scholars and academics with a complicated up to date textbook masking the main components of present curiosity within the lipid box. The chapters are written for college kids and researchers acquainted with the final options of lipid metabolism yet who desire to extend their wisdom during this zone. the second one target is to supply a reference textual content for scientists who're approximately to go into the sphere of lipids, lipoproteins and membranes and who desire to research extra approximately this region of study. all the chapters were commonly up to date because the 4th version seemed in 2002. Key positive factors: * Represents a bridge among the superficial insurance of the lipid box present in uncomplicated biochemistry textual content books and the hugely really expert fabric contained in medical overview articles and monographs. * permits scientists to get to grips with contemporary advancements relating to their very own examine pursuits, and should aid scientific researchers and scientific scholars maintain abreast of advancements in easy technology which are vital for next medical advances. * Serves as a normal reference e-book for scientists learning lipids, lipoproteins and membranes and as a sophisticated and up to date textbook for academics and scholars who're conversant in the elemental ideas of lipid biochemistry
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Extra resources for Biochemistry of lipids, lipoproteins and membranes : (5th edn.)
In E. coli lacking PE but genetically engineered to synthesize the neutral glycan lipid MGlcDG, LacY assumes its native topological organization and functions in uphill transport of substrate (J. Xie, 2006). The extramembrane domains of LacY, which are sensitive to lipid composition (those of the N-terminal six transmembrane helical bundle), carry a net positive charge and also each contains one or more acidic amino acids that lie within the interface region of the membrane. Substitution of any one of these acid residues with a neutral amino acid prevents mis-orientation of the whole helical bundle in cells lacking PE .
Therefore, both the topological organization and transport function of LacY are determined primarily by the phospholipid composition independent of cellular protein assembly machinery. Several secondary transport proteins with high overall structural homology to LacY are also dependent on PE for assembly and function. In the case of PheP (W. Zhang, 2003) and GapP , only the N-terminal helical hairpin (two transmembrane domains) are inverted in cells lacking PE. Therefore, the role of PE in determining topological orientation of transmembrane domains may be a general requirement for proper assembly of this family of secondary transport proteins.
16]. Copyright 1998 National Academy of Sciences, USA. (C) Crystal structure of FhuA complexed with lipopolysaccharide. The ribbon structure (blue) represents the outside surface of the barrel of FhuA with extended chains (yellow) of amino acids. The amino acids of the aromatic belt interact with the acyl chains (gray) and the basic amino acids interact with the phosphate (green and red) groups of Lipid A. The remainder of the lipopolysaccharide structure extends upward into the periplasm. Adapted from Ferguson et al.
Biochemistry of lipids, lipoproteins and membranes : (5th edn.) by Dennis E Vance