Download e-book for kindle: Carbohydrate Antigens by Per J. Garegg and Alf A. Lindberg (Eds.)

By Per J. Garegg and Alf A. Lindberg (Eds.)

ISBN-10: 0841213755

ISBN-13: 9780841213753

ISBN-10: 0841225311

ISBN-13: 9780841225312

content material: Michael Heidelberger : April 29, 1888-June 25, 1991 / Elvin A. Kabat --
How proteins realize and bind oligosaccharides / R.U. Lemieux --
Synthesis and immunological houses of glycopeptide T-cell determinants / Morten Meldal, Søren Mouritsen, and Klaus Bock --
Human fucosyltransferases serious about the biosynthesis of X (Gal-[beta]-1-4[Fuc-[alpha]-1-3]GlcNAc) and sialyl-X (NeuAC-[alpha]-2-3Gal-[beta]-1-4[Fuc-[alpha]-1-3]GlcNAc) antigenic determinants / Winifred M. Watkins, Patricia O. Skacel, and Philip H. Johnson --
Vibrio cholerae polysaccharide reviews / Bengt Lindberg --
Distinguishing antibodies that bind inner antigenic determinants from those who bind the antigenic chain-terminus in basic terms / Cornelis P.J. Glaudemans, Larry G. Bennett, Apurba ok. Bhattacharjee, Eugenia M. Nashed, and Thomas Ziegler --
Purification of oligosaccharide antigens through susceptible affinity chromatography / D.A. Zopf and W-T. Wang --
Synthesis and conformational research of the Forssman pentasaccharide and di-, tri-, and tetrasaccharide fragments / G. Magnusson, U. Nilsson, A.K. Ray, and K.G. Taylor --
Synthesis and immunochemistry of carbohydrate antigens of the [beta]-hemolytic streptococcus crew A / B. Mario Pinto --
Synthesis of antigenic heptose- and Kdo- containing oligosaccharides of the internal center area of lipopolysaccharides / H. Paulsen, E.C. Höffgen, and M. Brenken --
Molecular biology of anti-[alpha]-(1 [yields] 6)dextrans : antibody responses to a single-site-filling antigenic determinant / Elvin A. Kabat --
prolonged sort 1 chain glycosphingolipids : Lea-Lea (dimeric Lea) and Leb-Lea as human tumor linked antigens / Mark R. Stroud, Steven B. Levery, and Sen-itiroh Habomori.

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56 mmol) was added and the reaction was continued for 48 h at -20°. The violet product mixture was neutralized by addition of tetramethyl urea (116 μ \ , 1 mmol) and filtered through celite. The filtrate was washed with water and concentrated. MPLC chromatography yielded 301 mg (42 %) of the building block 5 and a small amount of the glycosylated free acid (86 mg, 13 %) as amorphous solids. 9° (c=l in CDC1 ). Anal. calc. 71. 11. 25 D 3 + 1 + 2 3 a FAB-MS: Calc. 9. H-NMR data for the oligosaccharide are presented in Table 2.

Both structures have been identified as human tumour markers and as ligands in cellular adhesion reactions mediated by endo­ genous lectins (LEC-CAMS). X structures are biosynthesised by a family of GDP-fucose:-N­ -acetyl-D-glucosaminide α-3-L-fucosyltransfer­ ases. The obligatory pathway for biosynthesis of sialyl-X i s first the formation of NeuAc α2-3-Gal-β-1-4GlcNAc, followed by the addition of the fucosyl residue to the N-acetylglucosamine unit. Not all α-3-fucosyltransferase species that synthesise X determinants can add fucose to the GlcNAc residue in NeuAcα-23Gal-β-1-4-GlcNAc to form sialyl-X determin­ ants.

Cameron, L. ; Holder, J. ; Sheppard, R. C. J. Chem. Soc. Perkin Trans. 1. 1988, 2895. 30. ; Duus, J. ; Pedersen, S. Carbohydr. ,1991, 211, 219. 31. ; Holm, A. Scand. J. Immunol. 1988, 28, 261. RECEIVED April 15, 1992 Chapter 4 Human Fucosyltransferases Involved in the Biosynthesis of X (Gal-β-1-4[Fuc-α1-3]GlcNAc) and Sialyl-X (NeuAC-α-2-3Gal-β-1-4[Fuc-α1-3]GlcNAc) Antigenic Determinants 1 2 3 Winifred M. Watkins , Patricia O. Skacel , and Philip H. ch004 1 Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 ONN, England Department of Haematology, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, England Medical Research Council Human Biochemical Genetics Unit, University College, London NW1 2HE, England 2 3 The X structure (Gal-β-1-4[Fuc-α-1-3]GlcNAc) occurs in glycoproteins, glycolipids, and free oligosaccharides and may be exposed as a terminal non-reducing end-group or masked by substitution with other sugars.

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Carbohydrate Antigens by Per J. Garegg and Alf A. Lindberg (Eds.)

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