Cellular Aspects of Smooth Muscle Function - download pdf or read online

By C. Y. Kao (editor), Mary E. Carsten (editor)

ISBN-10: 051175938X

ISBN-13: 9780511759383

ISBN-10: 0521018609

ISBN-13: 9780521018609

ISBN-10: 0521482100

ISBN-13: 9780521482103

This booklet presents an updated evaluate of our knowing of gentle muscle and integrates molecular, mobile and physiological info with tissue and anatomical stories. recognized researchers have written chapters giving distinct stories of our present wisdom of the biochemistry, pharmacology, body structure, and anatomy of soft muscle. particularly, they conceal the seven most vital parts of gentle muscle functionality together with morphology, electrophysiology, mechanisms of electromechanical and pharmacomechanical coupling, calcium homeostasis, sign transduction, mechanics of contraction, and the contractile proteins.

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Smooth muscles contain other types of cells in addition to muscle cells, a further source of specific features. A feature common to all smooth muscles is the absence of a perimysium or equivalent structure. Among the intramuscular nonmuscle cells are vascular cells (mainly endothelial cells of capillaries and pericytes), interstitial cells, fibroblasts, mast cells, Schwann cells, and axons. Interstitial cells of Cajal are present in all the smooth muscles of the alimentary tract (Figure 12B). Mast cells are common in smooth muscles of the airways (Gabella 1991).

In the case of the bladder, an important link in the neuronal hypertrophy is the production of Nerve Growth Factor and possibly other neurotrophic factors by the hypertrophied muscle cells of the bladder (Steers et al. 1991). Hypertrophy is to a great extent reversible. In the urinary bladder after removal of the obstruction, the muscle volume returns to control values and the cell hypertrophy is reversed (Gabella and Uvelius 1994). However, the shape of the muscle cell profiles remains distorted, and large amounts of stroma produced during hypertrophy are not removed (Figure 18).

The rough sarcoplasmic reticulum of muscle cells must be involved in protein and glycoprotein synthesis, and it accounts for the secretory activity of the cells, especially as regards elements of the intercellular stroma. Other organelles found in smooth muscle cells include lysosomes (Figure 3), Golgi apparatus, and ribosomes. Occasionally there are large dense-cored vesicles, multivescicular bodies, lipid vacuoles, and clusters of glycogen granules. ) cells are mitochondria, rough sarcoplasmic reticulum, dense bodies, and dense bands.

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Cellular Aspects of Smooth Muscle Function by C. Y. Kao (editor), Mary E. Carsten (editor)

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