By Natanya Civjan
An authoritative examine the applying of chemical biology in drug discovery and development
Based at the award-winning Wiley Encyclopedia of Chemical Biology released in 2008, this publication explores the position of chemical biology in drug discovery and improvement. the 1st a part of the publication reports key rules and methods utilized in the layout and overview of drug applicants. the second one half elucidates organic mechanisms of definite illnesses, illuminating ways to enquire and aim those diseases.
Comprising conscientiously chosen reprints from the Encyclopedia in addition to new contributions from top students within the box, this e-book presents researchers in academia and with very important info to help within the improvement of novel brokers to regard affliction. Self-contained articles hide quite a few crucial subject matters, including:
- The layout, improvement, and optimization of drug candidates
- The pharmacokinetics and houses of drugs
- Drug delivery and delivery
- Natural items and normal product types as pharmaceuticals
- Biological mechanisms underlying future health and disease
- Treatment concepts for a variety of ailments, from HIV to schizophrenia
Chemical Biology is a top-notch advisor and reference for someone operating within the components of drug discovery and improvement, together with researchers in chemical biology and different fields comparable to biochemistry, medication, and pharmaceutical sciences
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Extra resources for Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease
16. Li H, Gao Z, Kang L, Zhang H, Yang K, Yu K, Luo X, Zhu W, Chen K, Shen J, Wang X, Jiang H. TarFisDock: a web server for identifying drug targets with docking approach. Nucleic Acids Res. 2006;34:W219–224. 17. Gao Z, Li H, Zhang H, Liu X, Kang L, Luo X, Zhu W, Chen K, Wang X, Jiang H. PDTD: a web-accessible protein database for drug target identiﬁcation. BMC Bioinf. 2008;9:104. 18. Yue JM, Xu J, Zhao Y, Sun HD, Lin ZW. Chemical components from Ceratostigma willmottianum. J. Nat. Prod. 1997;60:1031–1033.
Devel. 2005;8:27–31. Klebe G. Virtual ligand screening: strategies, perspectives and limitations. Drug Discov. Today 2006;11:580–594. Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA. Applying computational modeling to drug discovery and development. Drug Discov. Today 2006;11:806–811. Le´on D, Markel S. In silico technologies. In: Drug Target Identiﬁcation and Validation (Drug Discoveries Series). 2006, Boca Raton, FL, CRC Press. 40 COMPUTATIONAL APPROACHES TO DRUG DISCOVERY AND DEVELOPMENT Lindsay MA.
Model. 2007;47:1688–1701. 54. Sheridan RP, Korzekwa KR, Torres RA, Walker MJ. Empirical regioselectivity models for human cytochromes p450 3A4, 2D6, and 2C9. J. Med. Chem. 2007;50:3173–3184. FURTHER READING 39 55. Helma C, Kazius J. Artiﬁcial intelligence and data mining for toxicity prediction. Curr. -Aid. Drug Des. 2006;2:1–19. 56. Zheng M, Liu Z, Xue C, Zhu W, Chen K, Luo X, Jiang H. Mutagenic probability estimation of chemical compounds by a novel molecular electrophilicity vector and support vector machine.
Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease by Natanya Civjan