By H. H. Dale (auth.)
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Extra info for Ergebnisse der physiologie biologischen chemie und experimentellen pharmakologie
T h a t the nervous tissue participates in exchanges with cerebrospinal fluid, is proved b y m a n y qualitative studies in which the tissue has been analysed either chemically, or b y radioautography in the case of isotopically labelled material. Quantitatively, moreover, the studies with barbotage, in which a relatively constant level of sucrose or P A H was maintained in the subarachnoid fluid for some time, indicated t h a t these substances m a y achieve diffusion-equilibrium with the extracellular space of the cord in one to two hours.
Close to the respiratory and vasomotor centres, had no influence, so it was concluded that the sensitive sites for attack were not the centres near the floor of the IVth ventricle but elsewhere. Recently DORNER (1961) has shown that the passage of 4"K into the cerebrospinal fluid is concentration-dependent. When substances are injected into the cisterna magna, we m a y assume t h a t access to the active absorbing sites is limited, so t h a t we need not expect to find evidence for an active process; nevertheless the studies of DAvsoN, KLEEMAN and LEVlN [t952 (a), (b)], summarized by Table t, show t h a t in the rabbit absorption of p-aminohippurate (PAH) is greater than t h a t of sucrose, and t h a t thiocyanate and iodide both show a much higher absorption than 2~Na.
DOBBING (t 96t) has emphasized the care that must be exercised in interpreting this sort of experiment, however, since the results may simply reflect different metabolic activity rather than different barrier function. However, GRUHN (1957) states that in the newborn kitten the rate of uptake of *~PO, by the cerebrospinal fluid is the same as in the mother; moreover, uptake by the brain of the foetus was similar to that of the mother. Further experimental evidence on the nature of the blood-brain barrier 39 blood and brain during one hour after parenteral injection are smaller in embryonic and developing chicks and rats than in older animals, but the figures that they present are not absolutely convincing on this point.
Ergebnisse der physiologie biologischen chemie und experimentellen pharmakologie by H. H. Dale (auth.)