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By Daniel Sinnecker, Ralf J. Dirschinger (auth.), Bernd Nilius, Susan G. Amara, Thomas Gudermann, Reinhard Jahn, Roland Lill, Stefan Offermanns, Ole H. Petersen (eds.)

ISBN-10: 3642335209

ISBN-13: 9783642335204

ISBN-10: 3642335217

ISBN-13: 9783642335211

triggered pluripotent stem cells in cardiovascular research.- TRPs within the brain.- The channel body structure of the skin.

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In the cerebellum, Purkinje cell TRPC3 channels underlie the slow excitatory postsynaptic potential (EPSP) observed following parallel fibre stimulation. TRPC3 channel opening requires stimulation of metabotropic glutamate receptor 1 (mGluR1), activation of which can also lead to the induction of long term depression (LTD), which underlies cerebellar motor learning. LTD induction requires protein kinase C (PKC) and protein kinase G (PKG) activation, and whilst PKC phosphorylation targets are well established, virtually nothing is known about PKG 42 R.

2009). BDNF also induces synaptic potentiation at both neuromuscular junctions (NMJs) and synapses of the CNS through a Ca2+ dependent pathway. Pharmacological inhibition or morpholino-mediated knockdown of Xenopus TRPC1 (XTRPC1) can significantly attenuate the BDNF-induced potentiation of the frequency of spontaneous synaptic responses at the NMJ. XTRPC1 was required specifically in postsynaptic myocytes for BDNF-induced Ca2+ elevation and full synaptic potentiation at the NMJ, suggesting a previously underappreciated postsynaptic function of Ca2+ signalling in neurotrophin-induced synaptic plasticity (McGurk et al.

This capsaicin induced LTD was absent in the trpv1 KO mouse. This synaptic depression apparently is mediated via a presynaptic activation of calcineurin, a phosphatase known to decrease neurotransmission probably linked in DRG to TRPV1 (Wu et al. 2005). This inhibition of the excitatory transmission via TRPV1 activation has also been reported in the dentate granule cells. Cha´vez et al. (2010) showed that this depression of the synaptic communication was due to an internalization of the AMPA receptor in a calcineurin dependent manner.

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Reviews of Physiology, Biochemistry and Pharmacology, Vol. 163 by Daniel Sinnecker, Ralf J. Dirschinger (auth.), Bernd Nilius, Susan G. Amara, Thomas Gudermann, Reinhard Jahn, Roland Lill, Stefan Offermanns, Ole H. Petersen (eds.)


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