By John Vincent
Chromium exists in nature as complexes of 2 strong oxidation states – trivalent chromium(III) and hexavalent chromium(VI). even supposing trivalent chromium is needed in hint quantities for sugar and lipid metabolism in people and its deficiency can cause a affliction referred to as chromium deficiency; hexavalent chromium is poisonous and carcinogenic. As chromium compounds have been utilized in dyes and paints and the tanning of leather-based, those compounds are usually present in soil and groundwater at deserted business websites, now desiring environmental cleanup and remediation.
The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology takes a severe examine what the biochemical information point out approximately chromium's position within the physique and the organic mechanisms of its toxicology. themes lined include:
- What will we find out about the biochemical roles and mechanisms of chromium?
- Is chromium a vital point within the mammalian diet?
- Is chromium(III) powerful as a nutraceutical, a healing agent, and as a complement in animal feed?
- What is the biochemistry in the back of the toxicology of chromium(III) and chromium(VI):the mechanisms of metabolism, genetic and epigenetic results, and disruption of mobile signalling?
- What are the present chromium(VI) rules and positions from regulatory agencies?
The Bioinorganic Chemistry of Chromium: From Biochemistry to Environmental Toxicology is a crucial contribution to the bioinorganic and hint aspect biochemical fields to be able to discover a position at the bookshelves of bioinorganic chemists, biochemists, inorganic chemists, toxicologists, nutritionists and regulatory affairs professionals.
Chapter 1 creation – the present prestige of Chromium(III) (pages 1–6):
Chapter 2 Is Chromium crucial? The proof (pages 7–30):
Chapter three the tale of Glucose Tolerance issue (GTF) (pages 31–53):
Chapter four Is Chromium potent as a Nutraceutical? (pages 55–79):
Chapter five Is Chromium(III) powerful as a healing Agent? (pages 81–123):
Chapter 6 Biochemical Mechanisms (pages 125–167):
Chapter 7 Menagerie of Chromium supplementations (pages 169–188):
Chapter eight strength Use of Chromium within the Farm cattle (pages 189–193):
Chapter nine Toxicology of Chromium(III) (pages 195–213):
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Additional resources for The Bioinorganic Chemistry of Chromium
Also by this deﬁnition, chromium cannot be considered an essential element (see Chapter 6) as evidence at a molecular level currently is insufﬁcient at best. However, signiﬁcant research effort has been focused in this area in the last 20 years and may lead ultimately to a resolution of this issue. Thus, by a nutritional deﬁnition or a biochemical deﬁnition, chromium cannot be considered an essential element at this time. Nielsen  has also promoted some additional terms to address ‘possibly essential elements’: conditional essentiality, pharmacologically beneﬁcial and nutritionally beneﬁcial.
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M. (1997) Lack of toxicity of chromium chloride and chromium picolinate in rats. J. Am. Coll. , 16, 273– 279. 18. R. et al. (2011) Chromium is not an essential trace element for mammals: effects of a “low-chromium” diet. J. Biol. Inorg. , 16, 381–390. 19. E. D. (1986) Chromium deﬁciency after long-term total parenteral nutrition. Dig. Dis. , 31, 661–664. 20. , Atamian, S. E. (1979) Chromium deﬁciency during total parenteral nutrition. JAMA, 241, 496–498. 21. B. et al. (1977) Chromium deﬁciency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long term total parenteral nutrition.
The Bioinorganic Chemistry of Chromium by John Vincent